salt screening pka difference

  • Pharmaceutical Salts - Journal of Pharmaceutical Sciences

    screening techniques exist to facilitate selection of the salt most likely to exhibit the ..... the diffusion layer. The driving force for dissolution in Eq. 1 is the difference .... solubility of the free base and the pKa determine the maximum pH at which...

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  • salt selection in pharmaceutical product development - SlideShare

    Apr 28, 2015 ... selecting the salt form of a drug to improve the solubility of the drug is a very ... The difference between the pKa of the base and the acid must be ... When the appropriate screening strategies are engaged, then selection of salt...

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  • Developing an Appropriate Salt Form for an Active Pharmaceutical ...

    Dec 1, 2009 ... The theoretical basis and application of in situ salt screening has been ... bases, and their salts was used to derive a useful relation that enables one ... acids having pKA values less than 3.0 would form acceptable salt forms.

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  • The utility of sulfonate salts in drug development

    differences of >2 pH units between the pKa's are ... example (pKa 7.25) that salt formation will only occur ..... Bastin et al.26 reported on the salt screening of.

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  • Salt Screening and Selection - University of Utah

    Jul 19, 2006 ... pH-solubility profiles, pKa and salt formation. • Prediction of salt ... 2 pH units difference between the pKas of the base and the acid typically...

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  • Principles of salt formation - ( Keywords: Salts, Formation, Selection ...

    Aug 3, 2014 ... Following the formation of candidate salt forms, the optimal form is chosen for ... a critical parameter for salt selection, where the difference in the pKa values of the ... approach by allowing effective and efficient salt screening.

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  • Polymorph and salt screening - Crystallization Systems

    The challenges of polymorph and salt screening. • Crystallization ... be predicted based on pKa differences between the API and the acid or base), but also to...

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  • Development of Methods for the Determination of pKa Values

    Aug 8, 2013 ... When considering the influence of the solvent, the difference .... It is not possible to measure the limiting conductance of ions directly, but Λ0 for a salt may ..... This makes the method quite suitable for screening applications.56...

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    difference in pKa units of the ionizable group in the drug and in the acid or base is .... their influence on salt screening and the selection of optimal salt forms.

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  • An Overview of Solid Form Screening During Drug ... - ICDD

    Carry out a salt screen (if applicable) ... Salt? Free/Salt Form. Animal PK. Polymorph. Screening. Free Form .... pKa difference of 2 between API and counterion.

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